Higher orexin-A levels are associated with treatment response to clozapine in patients with schizophrenia: A cross-sectional study.

Po-Yu ChenChih-Chiang ChiuChin-Kuo ChangMong-Liang LuCho-Yin HuangChun-Hsin ChenMing-Chyi Huang

Published in: Journal of psychopharmacology (Oxford, England) (2024)

This cross-sectional study showed that higher levels of orexin-A are associated with treatment response to clozapine in patients with TRS. Future prospective studies examining changes in orexin-A level following clozapine treatment and the potential benefit of augmenting orexin-A signaling are warranted.

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