Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis.
Gellan Alaa Mohamed KamelHemat A ElarinyPublished in: Molecular biology reports (2023)
PIO mitigated TAM hepatotoxicity by decreasing apoptosis, inflammation, and oxidative stress. The protecting ability of PIO was accompanied by reducing Keap-1 and NF-κB and regulating Keap1/Nrf2/HO-1 and Sirt1/Notch1 signaling. A schematic diagram illustrating the protective effect of PIO against TAM hepatotoxicity. PIO prevented TAM-induced liver injury by regulating Nrf2/HO-1 and SIRT1/Notch1 signaling and mitigating oxidative stress, inflammation, and apoptosis.
Keyphrases
- oxidative stress
- diabetic rats
- molecular docking
- pi k akt
- signaling pathway
- ischemia reperfusion injury
- induced apoptosis
- drug induced
- cell cycle arrest
- protein protein
- dna damage
- molecular dynamics simulations
- cell proliferation
- high glucose
- epithelial mesenchymal transition
- cell death
- breast cancer cells
- endothelial cells
- inflammatory response
- toll like receptor
- immune response
- lps induced
- positive breast cancer
- heat shock protein
- data analysis