Electrochemical-modulated surface-enhanced Raman scattering (EC-SERS) integrates the benefits of SERS with electrochemical techniques. By controlling the electrode potential, Raman spectroscopy allows for the analysis of molecules with enhanced sensitivity and selectivity. With its large volume and high sample consumption, the traditional three-electrode electrochemical cell constrains the widespread adoption of EC-SERS. This study developed a versatile EC-SERS platform based on Ag nanowires-modified screen-printed electrode (AgNWs-SPE). Taking advantage of the dual functionality of AgNWs-SPE, this platform facilitates the successful in situ collection and sensitive detection of charged molecules. Experimental findings and theoretical calculations validate the platform's high sensitivity and selectivity mainly regulated by the applied potential, providing a universal approach for the highly sensitive and accurate detection of charged molecules.
Keyphrases
- sensitive detection
- label free
- gold nanoparticles
- quantum dots
- high throughput
- molecularly imprinted
- loop mediated isothermal amplification
- raman spectroscopy
- ionic liquid
- solid phase extraction
- ms ms
- single cell
- carbon nanotubes
- cell therapy
- room temperature
- solid state
- reduced graphene oxide
- density functional theory
- risk assessment
- stem cells
- molecular dynamics
- fluorescent probe
- mesenchymal stem cells
- low cost
- bone marrow
- structural basis