Genetic Associations with C-peptide Levels before Type 1 Diabetes Diagnosis in At-Risk Relatives.

Taylor M Triolo Hemang M Parikh Mustafa Tosur Lauric A FerratLu YouPeter A GottliebRichard D Oram Suna Onngut-Gumuscu Jeffrey P Krischer Stephen S Rich Andrea K SteckMaria J Redondo

Published in: The Journal of clinical endocrinology and metabolism (2024)

The type 2 diabetes-associated JAZF1 rs864745 T allele and higher T1D-GRS2 are associated with lower C-peptide AUC prior to diagnosis of type 1 diabetes, with implications for the design of prevention trials.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
insulin resistance
gene expression
copy number
metabolic syndrome