Diacerein-induced interleukin-1β deficiency reduces the inflammatory infiltrate and immunoexpression of matrix metalloproteinase-8 in periodontitis in rat molars.
Renata Cristina Lima SilvaEstela Sasso-CerriPaulo Sergio CerriPublished in: Journal of periodontology (2022)
Our results show an inhibitory effect of diacerein on IL-1β in the inflamed gingival mucosa of rat molars, decreasing the inflammatory infiltrate and immunoexpression of MMP-8, and restoring the collagen content.