The Lung Microbiome Predicts Mortality and Response to Azithromycin in Lung Transplant Patients with Chronic Rejection.
Michael P CombsJenna E LuthNicole R FalkowskiDavid S WheelerNatalie M WalkerJohn R Erb-DownwardElliot WakeamMichael W SjodingDaniel G DunlapAndrew J AdmonRobert P DicksonVibha N LamaPublished in: American journal of respiratory and critical care medicine (2024)
In lung transplant patients with chronic rejection, increased lung bacterial burden is an independent risk factor for mortality and predicts clinical response to azithromycin. Lung bacterial dysbiosis is associated with alveolar inflammation and may be promoted by underlying lung allograft dysfunction.