Testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex.
Titikorn ChunchaiNattayaporn ApaijaiPuntarik KeawtepDuangkamol MantorApiwan ArinnoWasana PratchayasakulSiriporn C ChattipakornSiripron C ChattipakornPublished in: Acta physiologica (Oxford, England) (2018)
These findings suggest that testosterone deprivation aggravates cognitive decline in obesity via increasing oxidative stress, glial activity and apoptosis.
Keyphrases
- cognitive decline
- oxidative stress
- mild cognitive impairment
- weight loss
- metabolic syndrome
- replacement therapy
- diabetic rats
- dna damage
- induced apoptosis
- type diabetes
- ischemia reperfusion injury
- endoplasmic reticulum stress
- neuropathic pain
- insulin resistance
- adipose tissue
- cell cycle arrest
- bariatric surgery
- weight gain
- heat shock
- functional connectivity
- high fat diet induced
- cognitive impairment
- spinal cord injury
- obese patients
- prefrontal cortex
- spinal cord
- skeletal muscle
- signaling pathway
- heat shock protein