The effect of epididymosomes on the development of frozen-thawed mouse spermatogonial stem cells after culture in a decellularized testicular scaffold and transplantation into azoospermic mice.

Maryam RahbarReza AsadpourZohreh Mazaheri

Published in: Journal of assisted reproduction and genetics (2024)

The DTM hydrogel containing 20 µg/mL epididymosomes or 10 ng/mL GDNF is a novel and safe culture system that can support SSC proliferation in vitro to obtain adequate SSCs for transplantation success. It could be a novel therapeutic agent that could recover deregulated SSCs in azoospermic patients.

Keyphrases

stem cells
end stage renal disease
newly diagnosed
ejection fraction
tissue engineering
prognostic factors
drug delivery
signaling pathway
extracellular matrix
metabolic syndrome
mesenchymal stem cells
hyaluronic acid
pregnancy outcomes