α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways.

Nawal M AlrasheedRaghad B AlammariTahani K AlshammariMaha A AlaminAbeer O AlharbiAsma S AlonaziAnfal F Bin DayelNouf M Alrasheed

Published in: BMC cardiovascular disorders (2023)

Tamsulosin may exert a cardioprotective effect by modulating the ILK-related TGF-β/Smad signaling pathway. Thus, tamsulosin may be a useful therapeutic approach for preventing MI.

Keyphrases

signaling pathway
transforming growth factor
epithelial mesenchymal transition
benign prostatic hyperplasia
lower urinary tract symptoms
pi k akt
induced apoptosis
heart failure
left ventricular
tyrosine kinase
oxidative stress