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Evaluation of tumor microenvironment and biomarkers of immune checkpoint inhibitor response in metastatic renal cell carcinoma.

Landon C BrownJason ZhuKunal DesaiEmily KinseyChester KaoYong Hee LeeSarabjot PablaMatthew Kyle LabriolaJennifer TranKonstantin H DragnevLaura J TafeFarshid DayyaniRajan T GuptaShannon McCallDaniel J GeorgeSean T GlennMary K NeslineSaby GeorgeMatthew ZibelmanCarl MorrisonMoshe C OrnsteinTian Zhang
Published in: Journal for immunotherapy of cancer (2022)
A 5-gene panel that was associated with improved ORR in a predominantly nivolumab monotherapy population of patients with mRCC was not predictive for radiographic response, PFS, or OS among patients with mRCC treated with ipilimumab and nivolumab.
Keyphrases
  • metastatic renal cell carcinoma
  • genome wide
  • copy number
  • clinical trial
  • combination therapy
  • transcription factor
  • african american
  • genome wide identification
  • study protocol