Evaluation of tumor microenvironment and biomarkers of immune checkpoint inhibitor response in metastatic renal cell carcinoma.
Landon C BrownJason ZhuKunal DesaiEmily KinseyChester KaoYong Hee LeeSarabjot PablaMatthew Kyle LabriolaJennifer TranKonstantin H DragnevLaura J TafeFarshid DayyaniRajan T GuptaShannon McCallDaniel J GeorgeSean T GlennMary K NeslineSaby GeorgeMatthew ZibelmanCarl MorrisonMoshe C OrnsteinTian ZhangPublished in: Journal for immunotherapy of cancer (2022)
A 5-gene panel that was associated with improved ORR in a predominantly nivolumab monotherapy population of patients with mRCC was not predictive for radiographic response, PFS, or OS among patients with mRCC treated with ipilimumab and nivolumab.