Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles.

Kihiro WakasaRyutaro TamuraShuhei OsakaHajime TakeiAkihiro AsaiHiroshi NittonoHiroyuki KusuharaHisamitsu Hayashi

Published in: Hepatology communications (2024)

This study provides proof of concept for efficient in vivo assessment of cholestasis-related genes in humanized bile acid profiles. Our platform offers a more time- and cost-effective alternative to conventional genetically engineered mice, increasing our understanding of BA-related pathogenesis such as Ped-CLD and expanding the potential for translational research.

Keyphrases

high fat diet induced
drug induced
monoclonal antibody
high throughput
type diabetes
insulin resistance
skeletal muscle
wild type
risk assessment
metabolic syndrome
adipose tissue
climate change
human health