Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study.
Gilberto SilvaIsabel Catarina DuarteInês BernardinoTânia MarquesInês R ViolanteMiguel Castelo-BrancoPublished in: Journal of neurodevelopmental disorders (2018)
The present study demonstrated impaired precision in rhythmic pacing behaviour in NF1 as compared with controls. We found a decreased recruitment of the cerebellum, a structure where inhibitory interneurons are essential regulators of rhythmic synchronization, and in deep brain regions pivotally involved in motor pacing. Our findings shed light into the neural underpinnings of motor timing deficits in NF1.