Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies.

Sahar Saleh Alghamdi Rasha Saad SulimanAmjad Sulaiman AlsaeedKhlood Khaled AlmutairiNorah Abdulaziz AljammazAbdulelah AltolayyanRizwan AliAlshaimaa Alhallaj

Published in: Drug design, development and therapy (2021)

The obtained results confirm that the bioactive compounds present in fenugreek seeds exhibit anticancer activity against several cancer cells that can mediate via tubulin polymerization inhibition. Although our study has evaluated the anticancer potential of Trigonella foenum-graecum as a promising natural source for new anticancer agents, fenugreek biological activity needs further research and investigations on their mechanism of action and toxicity profile.

Keyphrases

molecular docking
molecular dynamics simulations
oxidative stress
risk assessment
human health
climate change
oxide nanoparticles