Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/progenitor population(s) transiently present in the developing brain. Our recent preclinical study reveals a cell-lineage-of-origin and develops a chemopreventative therapeutic strategy.
Keyphrases
- signaling pathway
- pi k akt
- low grade
- high grade
- cell therapy
- induced apoptosis
- single cell
- epithelial mesenchymal transition
- cell proliferation
- young adults
- stem cells
- optical coherence tomography
- immune response
- oxidative stress
- resting state
- mesenchymal stem cells
- multiple sclerosis
- inflammatory response
- african american
- endoplasmic reticulum stress