Hypertension as a Novel Link for Shared Heritability in Age at Menarche and Cardiometabolic Traits.

Hsien-Yu FanKuo-Liong ChienYen-Tsung HuangJustin BoKai HsuYun-Yu ChenEn-Yu LaiJia-Ying SuTzu-Pin LuHung-Yuan LiShih-Yuan HsuYang Ching Chen

Published in: The Journal of clinical endocrinology and metabolism (2023)

Our study highlights the usefulness of cross-trait analyses for identifying shared etiology between age at menarche and cardiometabolic traits, especially early onset hypertension. The menarche-related loci may contribute to early onset hypertension through endocrinological pathways.

Keyphrases

early onset
blood pressure
late onset
genome wide
dna methylation
gene expression
arterial hypertension
genome wide association