Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids.
Neha ShardaTamaki IkuseElizabeth HillSonia GarciaSteven J CzinnAndrea BaffordThomas G BlanchardAditi BanerjeePublished in: Clinical Medicine Insights. Oncology (2021)
These findings indicated that AGP and MLT associated ER stress-mediated apoptotic metastatic colorectal cancer (mCRC) cell death through the IRE-1/XBP-1/CHOP signaling pathway. This novel combination could be a potential therapeutic strategy for mCRC cells.
Keyphrases
- cell death
- cell cycle arrest
- metastatic colorectal cancer
- induced apoptosis
- signaling pathway
- endoplasmic reticulum stress
- pi k akt
- squamous cell carcinoma
- small cell lung cancer
- diffuse large b cell lymphoma
- epithelial mesenchymal transition
- adverse drug
- anti inflammatory
- bone marrow
- induced pluripotent stem cells