Autophagy in the control and pathogenesis of parasitic infections.

George Ghartey-KwansahFrank Adu-NtiBenjamin AboagyeAmandus AnkobilEdward Eyipe EssumanYeboah Kwaku OpokuSamuel AbokyiEmmanuel Kwasi AbuJohnson Nyarko Boampong

Published in: Cell & bioscience (2020)

In this review, we sum up recent advances in autophagy to acknowledge and understand the interplay between host and parasites, focusing on target proteins for the design of therapeutic drugs. The target host proteins on the initiation of the ULK complex and PRRs-mediated recognition of PAMPs may provide strong potential for the design of therapeutic drugs against parasitic infections.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
plasmodium falciparum