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Targeting the EGFR and Immune Pathways in Squamous Cell Carcinoma of the Head and Neck (SCCHN): Forging a New Alliance.

Nabil F SabaZhuo Gerogia ChenMissak HaigentzPaolo BossiAlessandra RinaldoJuan Pablo RodrigoAntti Aarni MäkitieRobert P TakesPrimoz StrojanJan Baptist VermorkenAlfio Ferlito
Published in: Molecular cancer therapeutics (2020)
Despite the recent approval of immune-modulatory agents, EGFR inhibition continues to be a cornerstone in the management of squamous cell carcinoma of the head and neck (SCCHN) namely in combination with radiotherapy in the treatment of locoregionally advanced disease as well as in platinum-sensitive recurrent or metastatic disease in the first-line setting. Importantly, recent evidence has emerged supporting also an immune-modulatory effect of EGFR inhibition, and interest has now focused on utilizing these effects in the current treatment approaches for SCCHN. In this report, we review the rationale and evidence supporting the forging of this new alliance in optimizing the treatment of SCCHN.
Keyphrases
  • squamous cell carcinoma
  • small cell lung cancer
  • epidermal growth factor receptor
  • tyrosine kinase
  • clinical trial
  • locally advanced
  • early stage
  • radiation therapy
  • lymph node metastasis
  • rectal cancer