Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy.
Monica GagliardiRadha ProcopioGiuseppe NicolettiMaurizio MorelliMarco D'AmelioAldo QuattroneGrazia AnnesiPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)
Recently, the LRP10 gene has been associated with Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants in patients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not a frequent cause of PD and DLB in Southern Italy.
Keyphrases
- copy number
- mild cognitive impairment
- genome wide
- cognitive impairment
- end stage renal disease
- parkinson disease
- single cell
- newly diagnosed
- ejection fraction
- genome wide identification
- peritoneal dialysis
- dna methylation
- prognostic factors
- intellectual disability
- autism spectrum disorder
- transcription factor
- genome wide analysis