Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Hongfeng WangNana WangDelai XuQilian MaYang ChenShiqiang XuQin XiaYan ZhangJochen H M PrehnGuanghui WangZheng YingPublished in: Autophagy (2019)
Bafi A1: bafilomycin A1; EBSS: Earle's balanced salt solution; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTORC1: mechanistic target of rapamycin kinase complex 1; ROS: reactive oxygen species; RPS6KB/p70S6K: ribosomal protein S6 kinase B; TFEB: transcription factor EB; WT: wild type.
Keyphrases
- transcription factor
- reactive oxygen species
- oxidative stress
- wild type
- cell death
- dna damage
- dna binding
- simultaneous determination
- living cells
- protein protein
- protein kinase
- binding protein
- gene expression
- endoplasmic reticulum stress
- tyrosine kinase
- amino acid
- quantum dots
- liquid chromatography
- induced apoptosis
- single molecule
- diabetic rats
- ischemia reperfusion injury
- tandem mass spectrometry
- solid state
- heat shock protein
- high resolution mass spectrometry