Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.

Jiamin JinXiaomei TongYin-Li ZhangWeijie YangYerong MaPeipei RenFeng ZhouSong-Ying Zhang

Published in: Journal of assisted reproduction and genetics (2021)

Three novel compound heterozygous WEE2 variants were found in patients with pronucleus formation failure. This study provides new evidence that WEE2 mutations result in loss of function, which could result in fertilization failure.

Keyphrases

early onset
copy number
gene expression
genome wide