Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle.
Pieter A LeermakersAlexander H V RemelsRamon C J LangenAnnemie M W J ScholsHarry R GoskerPublished in: BMC pulmonary medicine (2020)
These data suggest that one bolus of IT-LPS results in a temporal modulation of mitochondrial clearance and biogenesis in both oxidative and glycolytic skeletal muscle, which is insufficient to result in a reduction of mitochondrial content.