Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells.

Zhongxia WangChunping JiangWei-Bo Chen Guang ZhangDongjun LuoYin CaoJunhua Wu Yitao DingBaorui Liu

Published in: BioMed research international (2014)

Baicalein exhibits prominent anti-HCC activity. This flavonoid induces apoptosis and protective autophagy via ER stress. Combination of baicalein and autophagy inhibitors may represent a promising therapy against HCC.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
cell death
oxidative stress
bone marrow