Effects of Food and Pharmaceutical Formulation on Desmopressin Pharmacokinetics in Children.

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Published in: Clinical pharmacokinetics (2017)

Bioequivalence data on two formulations of the same drug in adults cannot be readily extrapolated to children. This was the first study in children suggesting that the two desmopressin formulations are not bioequivalent in children at the currently approved dose levels. Furthermore, the effect of food intake was found to be clinically relevant. Sampling times for a future study were suggested. This sampling design should result in more informative data and consequently generate a more robust model.

Keyphrases

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