The effects of advanced age and serum α1 -acid glycoprotein on docetaxel unbound exposure and dose-limiting toxicity in cancer patients.

Hirotsugu KenmotsuChiyo K ImamuraAkira OnoShota OmoriKazuhisa NakashimaKazushige WakudaTetsuhiko TairaTateaki NaitoHaruyasu MurakamiToshiaki TakahashiHirotsugu Kenmotsu

Published in: British journal of clinical pharmacology (2017)

Regardless of ageing, serum level of AAG determines docetaxel unbound exposure and related dose-limiting toxicity. Serum AAG level and ANC at baseline appear to be predictive of neutropenia for patients of all ages following the administration of docetaxel.

Keyphrases

end stage renal disease
locally advanced
newly diagnosed
chronic kidney disease
ejection fraction
oxidative stress
prognostic factors
rectal cancer
oxide nanoparticles