Amniotic fluid proteomic signatures of cervical insufficiency and their association with length of latency.
Rachelle N M GoviaKenzie D BirseShadi SepehriEhsan KhafipourSavas M MenticoglouAdam D BurgenerVanessa PoliquinPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
In this pilot study, significant differences in the amniotic fluid proteomic profiles in cases of cervical insufficiency compared to genetic amniocentesis were observed. Proteomic signatures were predictive of achieving latency > 1 week after diagnosis of cervical insufficiency. These preliminary findings suggest that proteomic analysis may be of value in predicting outcome following cervical insufficiency and warrants further validation in larger studies.
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