Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea.

Yaling WangBen WangYingxue HuangYangfan LiSha YanHongfu XieYiya ZhangJi Li

Published in: Journal of inflammation research (2022)

In conclusion, our results showed that the destruction of the skin barrier aggravates the inflammation levels and immune infiltration of rosacea partly by activating STAT3-mediated cytokine signal pathways in keratinocytes.

Keyphrases

wound healing
oxidative stress
soft tissue
diabetic rats
cell proliferation
high glucose
signaling pathway