DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review.
Virginia Veronica ViscontiIda CariatiSimona FittipaldiRiccardo IundusiElena GasbarraUmberto TarantinoAnnalisa BottaPublished in: International journal of molecular sciences (2021)
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.
Keyphrases
- dna methylation
- bone mineral density
- gene expression
- postmenopausal women
- genome wide
- late onset
- systematic review
- body composition
- rheumatoid arthritis
- healthcare
- knee osteoarthritis
- early onset
- copy number
- soft tissue
- public health
- mental health
- bone regeneration
- bone loss
- meta analyses
- social media
- case control
- health information