Altered patterning of neural activity in a tauopathy mouse model.

We expose differences in WT and tau brains, emerging at the circuit level, using a novel, morphological perspective on neural activity. This approach allows identifying qualitative changes in spiking patterns and in extracellular field oscillations, that are not discernible through traditional time-localized or time-averaged analyses. In particular, analyses of activity patterns facilitates detection of neurodegenerative deviations, conspicuously linking their effects to behavior and locomotion, thus opening a new venue for understanding how the architecture of neural activity shifts from normal to pathological.