Calpain Inhibitor Calpeptin Improves Pancreatic Fibrosis in Mice with Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells.

Jie ShenWenqin XiaoGuanzhao ZongPengli SongChuanyang WangJingpiao BaoQi PengZhu MeiJingjing WangRuiyan WangJing JiangRong WanJianbo NiXingpeng Wang Guoyong Hu

Published in: Current molecular pharmacology (2024)

These results suggest that the calpain inhibitor, calpeptin, plays a key role in the regulation of PSC activation by inhibiting the TGF-β1/smad3 signaling pathway, which supports the potential of calpeptin as an inhibitor of pancreatic fibrosis in mice by interfering with calpain.

Keyphrases

signaling pathway
induced apoptosis
epithelial mesenchymal transition
transforming growth factor
high fat diet induced
pi k akt
cell cycle arrest
endoplasmic reticulum stress
metabolic syndrome
climate change