ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial-mesenchymal transition in hepatocellular carcinoma.

Jieqiong LiNan HaoJuan HanMi ZhangXiaomei LiNan Yang

Published in: Cancer cell international (2020)

We demonstrate for the first time that ZKSCAN3 is overexpressed in HCC tissues and promotes migration, invasion and EMT process through ITGB4-dependent FAK/AKT activation, which was regulated by miR-124, suggesting the potential therapeutic value for HCC.

Keyphrases

epithelial mesenchymal transition
cell migration
signaling pathway
cell proliferation
transforming growth factor
long non coding rna
gene expression
long noncoding rna