2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains.

Sambashiva BanalaAriana N TkachukRonak PatelPratik KumarTimothy A BrownLuke D Lavis

Published in: ACS bio & med chem Au (2022)

Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties.

Keyphrases

fluorescent probe
small molecule
high resolution
living cells
oxidative stress
aqueous solution
quantum dots
energy transfer
optical coherence tomography
genome wide
protein protein
magnetic resonance imaging
mass spectrometry