Paradoxical effects of cigarette smoke and COPD on SARS-CoV2 infection and disease.
M TomchaneyM ContoliJ MayoS BaraldoL ShuaizhiC R CabelD A BullS LickJ MaloS KnoperS S KimJ TramJ Rojas-QuinteroM KraftJ LedfordYohannes TesfaigziF D MartinezC A ThorneF KheradmandS K CamposA PapiFrancesca PolverinoPublished in: bioRxiv : the preprint server for biology (2020)
ACE2 levels were decreased in both bronchial and alveolar epithelial cells from uninfected COPD patients versus controls, and from CS-exposed versus air-exposed mice. CS-pre-treatment did not affect ACE2 levels but potently inhibited SARS-CoV-2 replication in this in vitro model. These findings urge to further investigate the controversial effects of CS and COPD on SARS-CoV2 infection.
Keyphrases
- chronic obstructive pulmonary disease
- sars cov
- lung function
- respiratory syndrome coronavirus
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- angiotensin ii
- angiotensin converting enzyme
- prognostic factors
- hiv infected
- type diabetes
- patient reported outcomes
- adipose tissue
- coronavirus disease
- wild type