European multi-centre study to establish MIC and zone diameter epidemiological cut-off values for Bacillusanthracis.

Flavia DematheisViviana ManzulliGregor GrassErika MatuschekDaniela JacobFalk MelzerMandy ElschnerAgnieszka Kedrak-JablonskaSylwia BudniakMarcella MoriTiziano FancelloRoland GrunowGunnar KahlmeterDomenico GalanteSabine Zange

Published in: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (2024)

B. anthracis antimicrobial susceptibility testing results were used by EUCAST to determine ECOFFs for ten antimicrobial agents. The MIC distributions were used in the process of determining clinical breakpoints. The ECOFFs can be used for the sensitive detection of isolates with resistance mechanisms, and for monitoring resistance development. Genetic changes causing phenotypic shifts in isolates displaying slightly elevated MICs remain to be investigated.

Keyphrases

sensitive detection
quantum dots
genetic diversity
staphylococcus aureus
genome wide
loop mediated isothermal amplification
atomic force microscopy
dna methylation
optic nerve
mass spectrometry
single molecule