Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.

Emilia Liana FalconeLoreto AbuslemeMuthulekha SwamydasMichail S LionakisLi DingAmy P HsuAdrian M ZelaznyNiki M MoutsopoulosDouglas B KuhnsClay DemingMariam QuiñonesJulia A SegreClare E BryantSteven M Holland

Published in: Microbiome (2016)

Our findings suggest that the microbiome signature established at birth may play a bigger role than phagocyte-derived reactive oxygen species in mediating colitis susceptibility in CGD mice. These data further support bacteria-related disease in CGD colitis.

Keyphrases

reactive oxygen species
high fat diet induced
ulcerative colitis
electronic health record
big data
type diabetes
gestational age
machine learning
pregnant women
insulin resistance
data analysis
preterm birth
drug induced