Alpha-1 Asthma Overlap Syndrome: a Clinical Overview.
Manuel IzquierdoHimanshu RawalMichael ArmstrongChad R MarionPublished in: Current allergy and asthma reports (2022)
Recent literature suggests that there is an association between asthma and AATD. This association has been hypothesized to be secondary to an imbalance of elastase and anti-elastase leading to a pro-inflammatory state in patients with AATD. This review serves to overview the pathophysiology, clinical manifestations, and treatment of alpha-1 antitrypsin, asthma, and the increasingly recognized intersection of the two, AATD-asthma overlap syndrome.