Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy.

Published in: Animal models and experimental medicine (2020)

Lamotrigine-pentylenetetrazole kindling takes longer to develop (~5 weeks) in comparison to lamotrigine-amygdale (~4 weeks) and lamotrigine-corneal (~2 weeks) kindling models. However, drug screening through this model may yield superior drugs with novel antiseizure mechanisms.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
gestational age
emergency department
type diabetes
high fat diet induced
metabolic syndrome
adipose tissue
drug induced
preterm birth
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