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TRIM for Tissue Specificity.

Marcus D Hartmann
Published in: ACS medicinal chemistry letters (2023)
Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to the most ubiquitously expressed representatives. Unlocking of the TRIM58 ligase might represent a promising step toward tissue-specific PROTACs and molecular glue degraders.
Keyphrases
  • lymph node
  • small molecule
  • cancer therapy
  • protein protein
  • current status
  • amino acid
  • binding protein
  • single molecule
  • drug delivery
  • free survival