CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors.

Sara LabianoVincent RohCéline GodfroidAgnès Hiou-FeigeJackeline RomeroEva SumMoritz RappGael BoivinTania Wyss LozanoChristian SimonJean BourhisPablo UmañaChristine TrumpfhellerGenrich V TolstonogMarie-Catherine VozeninPedro Romero

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our study provides proof of concept, as well as mechanistic insights of the therapeutic efficacy of a bispecific FAP-CD40 combined with local radiotherapy in a FAP+-HNSCC model increasing overall survival and inducing long-term antitumor immunity.

Keyphrases

early stage
locally advanced
radiation therapy
radiation induced
nk cells
high grade
cancer therapy
squamous cell carcinoma
protein protein
binding protein
small molecule
amino acid
drug delivery