Metformin shows anti-neoplastic properties by inhibition of oxidative phosphorylation and glycolysis in epidermolysis bullosa-associated aggressive cutaneous squamous cell carcinoma.

Tobias WelponerD D WeberL TrattnerB TocknerS Aminzadeh-GohariV Leb-ReichlA KaufmannR ZaunerM WimmerV WallyT K FelderD StrunkU KollerJ W BauerB KoflerC Guttmann-GruberJ Piñon Hofbauer

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

Our data indicate that metformin exerts anti-neoplastic properties in aggressive cSCCs that exhibit high-risk features by interfering with respiration and glycolytic processes.

Keyphrases

squamous cell carcinoma
electronic health record
big data
protein kinase
machine learning
radiation therapy