Metabolic patterns across core features in dementia with lewy bodies.
Silvia MorbelliAndrea ChincariniMatthias BrendelAxel RomingerRose BruffaertsRik VandenbergheMilica G KrambergerMaja TrostValentina GaribottoNicolas NicastroGiovanni B FrisoniAfina W LemstraJessica van der ZandeAndrea PilottoAlessandro PadovaniSara Garcia-PtacekIrina SavitchevaMiguel A Ochoa-FigueroaAnnette DavidssonValle CamachoEnrico PeiraDario ArnaldiMatteo BaucknehtMatteo PardiniGianmario SambucetiDag AarslandFlavio NobiliPublished in: Annals of neurology (2019)
Regions of more preserved metabolism are relatively consistent across the variegate DLB spectrum. By contrast, core features were associated with more prominent hypometabolism in specific regions, thus suggesting a close clinical-imaging correlation, reflecting the interplay between topography of neurodegeneration and clinical presentation in DLB patients. Ann Neurol 2019;85:715-725.