DNA damage induced PARP-1 overactivation confers paclitaxel-induced neuropathic pain by regulating mitochondrial oxidative metabolism.

Meng-Meng GeJun-Jie HuYa-Qun ZhouYu-Ke TianZhi-Heng LiuHui YangYi-Rong ZhouQiu QiuDa-Wei Ye

Published in: CNS neuroscience & therapeutics (2024)

The findings provide a novel insight into the mechanism of DNA oxidative damage in the development of PINP and implicate PARP-1 as a possible therapeutic target for clinical PINP treatment.

Keyphrases

dna damage
neuropathic pain
oxidative stress
dna repair
diabetic rats
high glucose
spinal cord
drug induced
endothelial cells
circulating tumor cells