In vivo validation of late-onset Alzheimer's disease genetic risk factors.

Michael SasnerChristoph PreussRavi S PandeyAsli UyarDylan GarceauKevin P KotredesHarriet WilliamsAdrian L OblakPeter Bor-Chian LinBridget PerkinsDisha SoniCindy IngrahamAudrey Lee-GosselinBruce T LambGareth R Howell Gregory W Carter

Published in: bioRxiv : the preprint server for biology (2023)

These results provide an initial functionalization of 11 candidate risk variants and identify potential preclinical models for testing targeted therapeutics.

Keyphrases

late onset
risk factors
early onset
copy number
cognitive decline
small molecule
genome wide
cancer therapy
human health
climate change
risk assessment
bone marrow
mild cognitive impairment