Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer.

Samara P Singh Austin R Dosch Siddharth Mehra Iago De Castro Silva Anna Bianchi Vanessa T Garrido Zhiqun Zhou Andrew Adams Haleh Amirian Edmond W Box Xiaodian Sun Yuguang J Ban Jashodeep Datta Nagaraj S Nagathihalli Nipun B Merchant

Published in: Cancer research (2024)

Inhibition of p38 MAPK suppresses tumor cell-derived IL1α and attenuates the inflammatory stroma and immunosuppressive tumor microenvironment to overcome chemotherapeutic resistance in pancreatic cancer.

Keyphrases

oxidative stress
single cell
signaling pathway
bone marrow
cell therapy