The Relationship Between Glycated Hemoglobin and Time in Range in a Pediatric Population.

In adults with type 1 diabetes (T1D), time in range (TIR) [70-180 mg/dL] has been proposed as an additional metric besides glycated hemoglobin (HbA1c). This retrospective monocentric cohort study determined the correlation between HbA1c and TIR during the 2, 4, and 12 weeks (TIR 2w , TIR 4w , and TIR 12w ) before consultation in a pediatric T1D population. A total of 168 children with T1D were included. Continuous glucose monitoring data, HbA1c, and demographic variables were collected. We found strong linear correlations between HbA1c and TIR 2w ( R  = -0.571), HbA1c and TIR 4w ( R  = -0.603), and between HbA1c and TIR 12w ( R  = -0.624). A strong correlation exists between TIR 2w and TIR 12w , HbA1c and time above range (TAR), and between TIR and TAR at different time points. In conclusion, a strong correlation was found between HbA1c and TIR, making TIR a potentially complementary metric to HbA1c. TIR 2w seems a viable alternative to TIR 12w . TAR also seems promising in assessing glycemic control.