DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.

Cheng ZengGuoping QiYing ShenWenjing LiQi ZhuChunxia YangJianzhong DengWenbin LuQian LiuJianhua Jin

Published in: Cancer medicine (2022)

Our findings reveal that the DPEP1 enhances the stemness of tumor cells by forming a positive feedback loop with ASCL2 to improve resistance to chemotherapy drugs.

Keyphrases

transcription factor
stem cells
epithelial mesenchymal transition
genome wide
locally advanced
squamous cell carcinoma
radiation therapy
dna methylation
signaling pathway