Comparison of the efficacy and safety of methotrexate alone or in combination with leflunomide in the treatment of juvenile idiopathic arthritis: a double-blind, placebo-controlled, randomized trial.
Zahra RezaieyazdiSahar RavanshadMandana KhodashahiMaliheh BokaeianHassan Mehrdad-MajdMasoumeh SalariPublished in: Reumatologia (2023)
The results of this study showed that combining LFN with MTX does not improve clinical outcomes of JIA and may increase side effects in patients who do not respond to MTX.