Intracellular Zn(II) induced turn-on fluorescence of an L-phenylalanine-derived pseudopeptide.

Arpna TamrakarPraveen KumarNeha Garg Santiago Vicente Luis Mrituanjay D Pandey

Published in: Organic & biomolecular chemistry (2023)

A C 2 symmetric L-phenylalanine-derived pseudopeptide has been synthesized for selective and sensitive recognition of Zn(II) ions in aqueous-organic media. The pseudopeptidic probes exhibit intracellular Zn(II) ion-sensing capabilities as demonstrated via live-cell fluorescence studies on RAW264.7 cells. Hence, we present a bioinspired pseudopeptide for potential biological applications involving intracellular Zn(II) ion detection.

Keyphrases

heavy metals
single molecule
induced apoptosis
small molecule
living cells
risk assessment
cell cycle arrest
quantum dots
high glucose
oxidative stress
climate change
fluorescent probe
photodynamic therapy
sensitive detection
drug induced
loop mediated isothermal amplification