Correlation Between Serum and CSF Concentrations of Midazolam and 1-Hydroxy-Midazolam in Critically Ill Neurosurgical Patients.

Julie E FarrarSylvia S StefanosLuis CavaTyree H KiserScott W MuellerRobert NeumannPaul M ReynoldsDeb S ShermanRobert MacLaren

Published in: The Annals of pharmacotherapy (2024)

Continuous infusions of MZ result in measurable concentrations of MZ and 1-OH-MZ in CSF; however, CSF concentrations of MZ and 1-OH-MZ poorly represent serum concentrations or dosages. Accumulation of MZ and 1-OH-MZ in serum or CSF over time was not evident. Concentrations of MZ and 1-OH-MZ do not predict sedation levels, reinforcing that pharmacodynamic assessments are warranted.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
intensive care unit
patient reported outcomes
acute respiratory distress syndrome
extracorporeal membrane oxygenation