Single-cell sequencing of PIT1-positive pituitary adenoma highlights the pro-tumour microenvironment mediated by IFN-γ-induced tumour-associated fibroblasts remodelling.
Liang LyuYong JiangWeichao MaHaiyan LiXiaoling LiuLi LiAo ShenYang YuShu JiangHuihui LiPeizhi ZhouSenlin YinPublished in: British journal of cancer (2023)
Our study builds up a cellular landscape of PIT1-PA TME and highlights anti-tumour function of IFN-γ mediated TAF remodelling, which benefits clinical treatments and drug development.